李霄霞,青岛大学基础医学院遗传学与细胞生物学教研室,博士,讲师。
一、个人简介
女,1989年8月,汉族,中共党员。2017年8月加入青岛大学医学部基础医学院工作。2012年9月至2017年7月,博士就读于中国医学科学院/北京协和医学院基础医学研究所细胞生物学专业,导师赵春华教授。2008年9月至2012年7月本科就读于山东大学生命科学学院生物科学专业。
二、主要研究方向
(1) 间充质干细胞的免疫调控作用
(2) 间充质干细胞的衰老机制研究
三、代表性科研成果
(1)Cui X#, Li X#, He Y, Yu J, Fu J, et al. (2021) Combined NOX/ROS/PKC Signaling Pathway and Metabolomic Analysis Reveals the Mechanism of TRAM34-Induced Endothelial Progenitor Cell Senescence. Stem Cells Dev 30: 671-682.
(2)Cui X#, Li X#, He Y, Yu J, Dong N, et al. (2021) Slight up-regulation of Kir2.1 channel promotes endothelial progenitor cells to transdifferentiate into a pericyte phenotype by Akt/mTOR/Snail pathway. J Cell Mol Med 25: 10088-10100.
(3)Fu J, Cui X, Zhang X, Cheng M, Li X, et al. (2021) The Role of m6A Ribonucleic Acid Modification in the Occurrence of Atherosclerosis. Front Genet 12: 733871.
(4)Xiao X, Xu M, Yu H, Wang L, Li X, et al. (2021) Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src. Signal Transduct Target Ther 6: 354.
(5)Wang S, Su X, Xu M, Xiao X, Li X, Li H, Keating A, Zhao RC. Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway.Stem Cell Res Ther. 2019 Apr 11;10(1):117.
(6)Wang S, Xu M, Li X, Su X, Xiao X, Keating A, Zhao RC. Exosomes released by hepatocarcinoma cells endow adipocytes with tumor-promoting properties.J Hematol Oncol. 2018 Jun 14;11(1):82.
(7)Gao J, Wang S, Tang Q, Li X, Zhang Y, Liu W, Gao Z, Yang H, Zhao RC.
In Vitro Survival of Human Mesenchymal Stem Cells is Enhanced in Artificial Endolymph with Moderately High Concentrations of Potassium.
Stem Cells Dev. 2018 May 15;27(10):658-670
(8) Shihua Wang# Xiaoxia Li#, Meiqian Xu,Jing Wang, Robert Chunhua Zhao*. Reduced adipogenesis after lung tumor exosomes priming in human mesenchymal stem cells via TGFβ signaling pathway. Molecular and Cellular Biochemistry. 2017 Nov;435(1-2):59-66.
(9)Xiaoxia Li#, Shihua Wang#, Rongjia Zhu, Hongling Li,Qin Han* ,Robert Chunhua Zhao *,“Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway”,Journal of Hematology & Oncology,2016 Apr 18;9:42.
(10) Shihua Wang# , Xiaoxia Li#, Rongjia Zhu, Qin Han* and Robert Chunhua Zhao *, “Lung cancer exosomes initiate global long-noncoding RNA changes in mesenchymal stem cells”, International journal of oncology 2016 Feb; 48(2): 681-9.
(11) Shihua Wang#, Xiaoxia Li#, Robert Chunhua Zhao, “Transcriptome Analysis of Long Noncoding RNAs in Toll-Like Receptor 3-Activated Mesenchymal Stem Cells”, Stem Cells International,2016:6205485.
四、主持和参与的科研项目
1. 人原始间充质干细胞临床前体内生物分布研究,横向课题研究,50万元,2021.3-2022.3,主持
2. 低氧处理的MSC来源外泌体诱导巨噬细胞M1/M2表型转换参与急性肾损伤修复的机制研究,青岛市博士后项目,5万元,2020.01-2021.12,主持
3. 多梳蛋白抑制复合体1.1调控人多能性表观遗传的机制研究,国家自然科学基金面上项目,32070859, 2021.01-2024.12,58万元,参与
4. 藻蓝蛋白活性肽筛选及其对生殖细胞RIP1/RIP3/MLKL信号通路的免疫调控研究,国家自然科学基金面上项目,81871231, 2019.01- 2022.12, 57万元,参与
五、科研奖励
1.李冰,褚现明,高美华,滕蕾,李霄霞。新型C-PC-CMC-CD55/CD59sp纳米微球的构建及其靶向抗肿瘤效应研究,山东省医学科技奖三等奖(2019年10月)
联系方式: E-mail:lixiaoxia0805@163.com