吴伟伟， 青岛大学生理学与病理生理学系，医学博士，讲师
一、 个人简介
博士毕业于山东大学医学院（2010/9～2016/6，硕博连读），后于美国南卡罗莱纳大学医学院任职及从事博士后研究（Research specialist II及博士后，2015/5～2020/1），目前于青岛大学基础医学院生理学与病理生理学系任教（2021/6～）。
二、 主要研究方向
心血管疾病及机制研究，移植静脉血管重构与药物治疗，细胞示踪技术与血管干细胞研究。
三、 代表性科研成果
1. Wu, W.; Hendrix, A.; Nair, S.; Cui, T. Nrf2-Mediated Dichotomy in the Vascular System: Mechanistic and Therapeutic Perspective. Cells 2022, 11, doi:10.3390/cells11193042.
2. Wu, W.; Qin, Q.; Ding, Y.; Zang, H.; Li, D.S.; Nagarkatti, M.; Nagarkatti, P.; Wang, W.; Wang, X.; Cui, T. Autophagy Controls Nrf2-Mediated Dichotomy in Pressure Overloaded Hearts. Front Physiol 2021, 12, 673145, doi:10.3389/fphys.2021.673145.
3. Wu, W.; Wang, C.; Zang, H.; Qi, L.; Azhar, M.; Nagarkatti, M.; Nagarkatti, P.; Cai, G.; Weiser-Evans, M.C.M.; Cui, T. Mature Vascular Smooth Muscle Cells, but Not Endothelial Cells, Serve as the Major Cellular Source of Intimal Hyperplasia in Vein Grafts. Arterioscler Thromb Vasc Biol 2020, 40, 1870-1890, doi:10.1161/ATVBAHA.120.314465.
4. Wu, W.; Xu, H.; Wang, Z.; Mao, Y.; Yuan, L.; Luo, W.; Cui, Z.; Cui, T.; Wang, X.L.; Shen, Y.H. PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury. PLoS One 2015, 10, e0132499, doi:10.1371/journal.pone.0132499.
5. Zang, H.; Wu, W.; Qi, L.; Tan, W.; Nagarkatti, P.; Nagarkatti, M.; Wang, X.; Cui, T. Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice. Diabetes 2020, 69, 2720-2734, doi:10.2337/db19-1176.
6. Qi, L.; Zang, H.; Wu, W.; Nagarkatti, P.; Nagarkatti, M.; Liu, Q.; Robbins, J.; Wang, X.; Cui, T. CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes. J Mol Cell Cardiol 2020, 145, 59-73, doi:10.1016/j.yjmcc.2020.06.004.
7. Mao, Y.; Luo, W.; Zhang, L.; Wu, W.; Yuan, L.; Xu, H.; Song, J.; Fujiwara, K.; Abe, J.I.; LeMaire, S.A.; et al. STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity. Arterioscler Thromb Vasc Biol 2017, 37, 920-929, doi:10.1161/ATVBAHA.117.309017.
8. Song, H.; Wang, H.; Wu, W.; Qi, L.; Shao, L.; Wang, F.; Lai, Y.; Leach, D.; Mathis, B.; Janicki, J.S.; et al. Inhibitory role of reactive oxygen species in the differentiation of multipotent vascular stem cells into vascular smooth muscle cells in rats: a novel aspect of traditional culture of rat aortic smooth muscle cells. Cell Tissue Res 2015, 362, 97-113, doi:10.1007/s00441-015-2193-9.
9. Li, W.; Wu, W.; Song, H.; Wang, F.; Li, H.; Chen, L.; Lai, Y.; Janicki, J.S.; Ward, K.W.; Meyer, C.J.; et al. Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of beta-cells in a setting of oxidative stress. FEBS Lett 2014, 588, 2115-2124, doi:10.1016/j.febslet.2014.04.046.
10. Zhang, X.; Guo, L.; Niu, T.; Shao, L.; Li, H.; Wu, W.; Wang, W.; Lv, L.; Qin, Q.; Wang, F.; et al. Ubiquitin carboxyl terminal hydrolyase L1-suppressed autophagic degradation of p21WAF1/Cip1 as a novel feedback mechanism in the control of cardiac fibroblast proliferation. PLoS One 2014, 9, e94658, doi:10.1371/journal.pone.0094658.
四、 主持的科研项目
1. 国家自然科学基金青年基金项目：Sca-1+血管干细胞的激活可促进移植静脉血管重构（82200465），2023/01/-2025/12，30万元，在研，主持。
2. 山东省自然科学基金博士基金项目：CDK8在血管平滑肌细胞表型转化和移植静脉重构中的作用机制研究（ZR2022QH008），2023/01/-2025/12，15万元，在研，主持。
五、 获得的学术奖励
1. Weiwei Wu; Rong Yin; Wenbin Tan; Mitzi Nagarkatti; Prakash Nagarkatti; Isidro Sanez-Garci a; Guoshuai Cai; gor B. Roninson; Taixing Cui; A novel subset of adventitial vascular stem cells paracrine control media smooth muscle cell dedifferentiation leading to intimal hyperplasia in ve in grafts, AHA Vascular Discovery: From Genes to Medicine 2021, a VIRTUAL meeting, 2021-9-22 to 2021-9-24
2. Weiwei Wu; Lei Qi; Huimei Zang; Mitzi Nagarkatti; Prakash Nagarkatti; Taixing Cui; It is not differentiation but paracrine regulation of vascular stem cell (VSC) that is essential forneo intimal hyperplasia in vein grafts, 2019 Center for Complementary and alternative medicine/COBRE External Advisory Committee Meeting, Coulumbia,SC, 2019-3-28 to 2019-3-28
3. Weiwei Wu; Chunyang Wang; Christopher Bowen; Lorne J. Hofseth; Mitzi Nagarkatti; Prakash Nagarkatti; Taixing Cui; The effect of American ginseng on macrophage phenotype switch and vascu lar repair, The 7th Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE), Washington, DC, 2018-6-24 to 2018-6-26
联系方式：青岛大学浩园C922；weiwei.wu@qdu.edu.cn
