狄国虎，青岛大学基础医学院特种医学系，博士，教授，硕士生导师

一、个人简介：青岛大学基础医学院长助理，山东省高校青创团队带头人，青岛大学优秀共产党员，青岛大学优秀研究生指导教师。师从于解放军军事医学研究院干细胞专家吴祖泽院士。代表性论文发表在Diabetes，Stem Cell Research&Therapy，FASEB J等期刊，承担干细胞国家重点研发计划子课题、国家自然基金面上项目、国家青年基金、山东省自然基金面上项目等课题。兼任中国医药生物技术协会再生医学分会委员，中国抗癌协会血液病转化委员会青年委员，《精准医学》青年编委，国家自然基金评审专家，Molecular Therapy, Cell Death Discovery 等杂志审稿人。

二、主要研究方向：1间充质干细胞及衍生物在重大疾病及组织再生中的免疫调控及转化应用；2巨噬细胞在重大疾病及组织再生的调控机制及转化应用

三、代表性论文

（1）Luan X, Chen P, Li Y, Yuan X, Miao L, Zhang P, Cao Q, Song X, Di G*.TNF-α/IL-1β-licensed hADSCs alleviate cholestatic liver injury and fibrosis in mice via COX-2/PGE2 pathway.Stem Cell Res Ther. 2023;14(1):100.

（2）Xu J, Chen P, Yu C, Shi Q, Wei S, Li Y, Qi H, Cao Q, Guo C, Wu X, Di G*.Hypoxic bone marrow mesenchymal stromal cells-derived exosomal miR-182-5p promotes liver regeneration via FOXO1-mediated macrophage polarization FASEB J. 2022 Oct;36(10):e22553

（3）Zhu CH, Zhang DH, Zhu CW, Xu J, Guo CL, Wu XG, Cao QL, Di GH*. Adult stem cell transplantation combined with conventional therapy for the treatment of end-stage liver disease: a systematic review and meta-analysis.Stem Cell Res Ther. 2021;12(1):558.

（4）Yu C, Chen P, Xu J, Liu Y, Li H, Wang L, Di G*. hADSCs derived extracellular vesicles inhibit NLRP3inflammasome activation and dry eye. Sci Rep. 2020 Sep 3;10(1):14521.

（5）Yu C, Chen P, Xu J, Wei S, Cao Q, Guo C, Wu X, Di G*.Corneal Epithelium-Derived Netrin-1 Alleviates Dry Eye Disease via Regulating Dendritic Cell Activation. Invest Ophthalmol Vis Sci. 2022;63(6):1.

（6）Xu J, Chen P, Luan X, Yuan X, Wei S, Li Y, Guo C, Wu X, Di G*.The NLRP3 Activation in Infiltrating Macrophages Contributes to Corneal Fibrosis by Inducing TGF-β1 Expression in the Corneal Epithelium. Invest Ophthalmol Vis Sci. 2022;63(8):15.

（7）Shi Q, Zhao G, Wei S, Guo C, Wu X, Zhao RC, Di G*. Pterostilbene alleviates liver ischemia/reperfusion injury via PINK1-mediated mitophagy. J Pharmacol Sci. 2022 Jan;148(1):19-30.

(8) Xu J, Chen P, Zhao G, Wei S, Li Q, Guo C, Cao Q, Wu X, Di G*. Copolymer Micelle-administered Melatonin Ameliorates Hyperosmolarity-induced Ocular Surface Damage through Regulating PINK1-mediated Mitophagy. Curr Eye Res. 2022 Mar 7;1-16

(9) Yu C, Chen H, Qi X, Chen P, Di G*, Annexin A1 mimetic peptide Ac2-26 attenuates mechanical injury induced corneal scarring and inflammation. Biochem Biophys Res Commun. 2019 Nov 5;519(2):396-401.

(10) Tang S#, Di G#, Hu S, Liu Y, Dai Y, Chen P. AQP5 regulates vimentin expression via miR-124-3p.1 to protect lens transparency.Exp Eye Res. 2021 Apr;205:108485.

(11) Liu Y#, Di G#, Hu S, Zhao T, Xu X, Wang X, Chen P. Expression Profiles of CircRNA and mRNA in Lacrimal Glands of AQP5 -/- Mice With Primary Dry Eye.Front Physiol. 2020 Sep 3;11:1010.

(12) Liu Y#, Di G#, Wang Y, Chong D, Cao X, Chen P. Aquaporin 5 Facilitates Corneal Epithelial Wound Healing and Nerve Regeneration by Reactivating Akt Signaling Pathway.Am J Pathol. 2021 Nov;191(11):1974-1985.

(13)Di GH, Qi X, Xu J, Yu CQ, Cao QL, Xing ZJ, Li ZC.Therapeutic effect of secretome from TNF-α stimulated mesenchymal stem cells in an experimental model of corneal limbal stem cell deficiency.Int J Ophthalmol. 2021 Feb 18;14(2):179-185

(14) Xu J, Chen P, Yu C, Liu Y, Hu S, Di G*. In vivo Confocal Microscopic Evaluation of Corneal Dendritic Cell Density and Subbasal Nerve Parameters in Dry Eye Patients: A Systematic Review and Meta-analysis. Front Med (Lausanne). 2021 Apr 7;8:578233.

(15) Li Y, Wei Z, Ma X, Xu J, Zhao X, Cao Q, Di G*.Efficacy and Safety of Mesenchymal Stromal cells Therapy for COVID-19.Curr Stem Cell Res Ther. 2021 Dec 6.

(16) Hu S#, Di G#, Cao X, Liu Y, Wang Y, Zhao H, Wang D, Chen P. Lacrimal gland homeostasis is maintained by the AQP5 pathway by attenuating endoplasmic reticulum stress inflammation in the lacrimal gland of AQP5 knockout mice. Mol Vis. 2021 Dec 7;27:679-690.

(17) Yu C, Chen P, Miao L, Di G*.The Role of the NLRP3 Inflammasome and Programmed Cell Death in Acute Liver Injury. Int J Mol Sci. 2023 ;24(4):3067.

(18) Cao X#, Di G#, Bai Y, Zhang K, Wang Y, Zhao H, Wang D, Chen P.Aquaporin5 Deficiency Aggravates ROS/NLRP3 Inflammasome-Mediated Pyroptosis in the Lacrimal Glands.Invest Ophthalmol Vis Sci. 2023;64(1):4.

(19) Shaohua H, Yihui W, Kaier Z, Ying B, Xiaoyi W, Hui Z, Guohu D**, Peng C*.Aquaporin 5 maintains lens transparency by regulating the lysosomal pathway using circRNA. J Cell Mol Med. 2023;27(6):803-818.

(20)Wang Y#, Di G#, Zhang K, Bai Y, Cao X, Zhao H, Wang D, Chen P.Loss of aquaporin 5 contributes to the corneal epithelial pathogenesis via Wnt/β-catenin pathway. FASEB J. 2023;37(2):e22776.

三、主持课题

1. 干细胞国家重点研发计划（子课题）：单细胞组学重建多能干细胞向肝脏命运决定关键机制（2018.08-2023.12）

2. 山东省高等学校青年创新团队：糖尿病眼表病变研究创新团队（2023.01-2025.12）

3. 山东省自然基金面上项目：间充质干细胞外泌体通过 miR-182-5p 促进糖尿病角膜上皮修复的作用及机制 （2023.01-2025.12）

4. 国家自然基金面上项目： VEGF-VEGFR1信号通路在维持角膜神经稳态中的作用及其分子机制 （2017.01-2020.12）

5. 国家博士后面上项目：脂肪干细胞外泌体促进糖尿病角膜损伤修复的作用及机制（2019.05-2020.12）

6. 横向课题：海尔生物干细胞合作项目（2019.07-2020.12）

联系方式：diguohu@qdu.edu.cn