主要学术成果 科研项目： 1.CT Innovations, Seed grant,M151372, Genome-wide shRNA screen identifies novel regulatory pathways in human ES cells，2012-11至2014-10，20万美元，结题，主持 2.国家自然科学基金，多梳蛋白抑制复合体1.1调控人多能性表观遗传的机制研究，2021.01-2024.12，58万元，主持 3.山东省自然科学基金，RING在人早期神经发育过程及相关疾病的表观遗传调控机制，2021.01-2023.12，10万元，主持 期刊论文： 1. Kevin R. Moon*, David van Dijk*,Zheng Wang*, Scott Gigante, Daniel B. Burkhardt, William S. Chen, Kristina Yim, Antonia van den Elzen, Matthew J. Hirn, Ronald R. Coifman, Natalia B. Ivanova, Guy Wolf & Smita Krishnaswamy. Visualizing structure and transitions in high-dimensional biological data. Nat Biotechnology 37, 1482-1492 (2019) (IF=35.724,并列第一作者) 2.Zheng Wang, Micah D. Gearhart, Yu-Wei Lee, Ishan Kumar, Bulat Ramazanov,4 Yan Zhang, Charles Hernandez, Alice Y. Lu, Nils Neuenkirchen, Jingjing Deng, Jiaqi Jin, Yuval Kluger, Thomas A. Neubert, Vivian J. Bardwell, and Natalia B. Ivanova A Non-canonical BCOR- PRC1.1 Complex Represses Differentiation Programs in Human ESCs. Cell Stem Cell 22, 235-251 e239 (2018) (IF=23.29) 3.Zheng Wang, Efrat Oron, Brynna Nelson, Spiro Razis, Natalia Ivanova. Distinct Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells. Cell Stem Cell 10, 440-454 (2012) (Highlighted as Best of 2012 in Cell Stem Cell, IF=23.29) 4. Charles Hernandez,Zheng Wang, Bulat Ramazanov, Yin Tang, Sameet Mehta, Cheryl Dambrot, Yu-Wei Lee, Kaleab Tessema, Ishan Kumar, Michael Astudillo, Thomas A. Neubert, Shangqin Guo, Natalia B. Ivanova. Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency. Cell Stem Cell 23, 396-411 e398 (2018). (IF=23.29) 5.Zheng Wang; Ting Wang; L. de Fabritus; B. Ramazanov; Tian Zhou; Sui Xu; T. Hornemann; S.A. van de Pavert; N.B. Ivanova; S.M. Kaech and F.R. Santori. Sphingolipids are natural ligands of COUP-TF driving heart and lymphatic vessel development. (Science, in revision) (IF= 37.205) 6.Zheng Wang, Yan Zhang, Yuwei Lee, Natalia Ivanova, Combining CRISPR/Cas9- mediated knockout with genetic complementation for in-depth mechanistic studies in human ES cells. Biotechniques 66, 23-27 (2019) (IF=2.098) 7. Pei-Yu Chen, Lingfeng Qin, Guangxin Li,Zheng Wang et al., Endothelial TGF-beta signalling drives vascular inflammation and atherosclerosis. Nat Metabolism 1, 912-926 (2019) 8. Ying Zhang, Vincent P. Schulz, Brian D. Reed,Zheng Wang, Xinghua Pan, Jessica Marian, Ghia Euskirchen, Michael P. Snyder, Flora M. Vaccarino, Natalia Ivanova, Sherman M. Weissmana, Anna M. Szekely. Functional genomic screen of human stem cell differentiation reveals pathways involved in neurodevelopment and neurodegeneration. Proceedings of the National Academy of Sciences. July 8, 2013 (IF= 9.504) 获奖情况： 2019.9山东省泰山学者特聘专家 |
