主 要 学 术 成 果:
科研项目：
1. 一种血浆生物标记物在帕金森病早期干预中的作用机制研究（2012CB526703），973计划前期研究专项课题，70万元，2012-2014。
2. 脑肠肽Ghrelin与帕金森病早期发生发展的关系研究（81171207），国家自然科学基金面上项目，62万元，2012-2015
3. 帕金森病早期非运动症状胃肠道功能障碍的中枢机制及早期干预研究（31471114），国家自然科学基金面上项目，86万元，2015-2018
4. 教育部新世纪优秀人才基金，50万元，2013-2016
5．帕金森病黑质铁选择性聚集和特异性损伤多巴胺能神经元的机制研究（ JQ200807），山东省自然科学杰出青年基金，50万元，2008-2012
6. 帕金森病外周血Ghrelin水平降低的原因及其机制研究（20103706110002） 教育部高等学校博士学科点专项科研基金 6万元， 2011-2013
7. 一种可用于临床早期诊断老年痴呆症的生物标记物研究（121034） 霍英东教育基金会高等院校青年教师基金基础性研究课题， 2万美元，2010-2013
著作教材：
副主编 《铁代谢失衡疾病的分子生物学原理》（人民卫生出版社）
参编《铁与人类健康》、《人体生理学》
期刊论文：
1. Shi L, Bian X, Qu Z, Ma Z, Zhou Y, Wang K*, Jiang H*, Xie J*. Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channels. Nat Commun. 4:1435, 2013
2. Jiang H, He P, Adler CH, Shill H, Beach TG, Li R, Shen Y*. Bid signal pathway components are identified in the temporal cortex with Parkinson disease. Neurology. 79(17):1767-73, 2012
3. Yu X, Du T, Song N, He Q, Shen Y, Jiang H*, Xie J*. Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson’s disease. Neurology, Jan 29;80(5):492-5.
4. Jiang H, He P, Xie J, Staufenbiel M, Li R, Shen Y*. Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα. Hum Mol Genet. 2014 Sep 15;23(18):4906-18.
5. Zhang Z, Du X, Xu H, Xie J, Jiang H*. Lesion of medulla’s catecholaminergic neurons is associated with cardiovascular dysfunction in rotenone-induced Parkinson’s disease rats. Eur J Neurosci. 2015 Sep;42(6):2346-55
6. Tan Z, Xu H, Shen X, Jiang H*. Nesfatin-1 antagonized rotenone-induced neurotoxicity in MES23.5 dopaminergic cells. Peptides. 2015 Jul;69:109-14.
7. Wang W, Song N, Jia F, Xie J, Zhang Q, Jiang H*. Neuroprotective effects of porphyran derivatives against 6-hydroxydopamine-induced cytotoxicity is independent on mitochondria restoration. Ann Transl Med. 2015 Mar;3(3):39
8. Hong Jiang, Ping He, Junxia Xie, Staufenbiel M, Li R, Shen Y*. Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα. Hum Mol Genet. 2014 Sep 15;23(18):4906-18.
9. Fengjv Jia, Ning Song, Chenyang Zhao, Junxia Xie, Hong Jiang*. Unexpected Improvements of Spatial Learning and Memory Abilities in Chronic Rotenone Intoxicated Mice. PLoS One. 2014 Mar 11;9(3):e91641.
10. Xiaoli Shen, Jianhan Yu, Dongfeng Zhang, Junxia Xie, Hong Jiang*. Positive relationshipbetween mortality from Alzheimer's disease and soil metal concentration inmainland China. J Alzheimers Dis. 2014;42(3):893-900.
11. Chen Li, Fang Zhang, Limin Shi, Haoyun Zhang, Zibin Tian, Junxia Xie, Hong Jiang*. Nesfatin-1 Decreases Excitability of Dopaminergic Neurons in the Substantia Nigra. J Mol Neurosci. 2014 Mar;52(3):419-24.
12. Xiaoli Shen, Fengjv Jia, Ning Song, Junxia Xie, Hong Jiang*. Protective effects of obestatin are mediated by proliferative rather than anti-apoptotic properties in MES23.5 dopaminergic cells. Neurosci Bull. 2014 Feb;30(1):118-24. doi: 10.1007/s12264-013-1405-0. Epub 2014 Jan 30.
13. He Q, Song N, Jia F, Xu H, YuX, Xie J, Jiang H*. Role of α-synuclein aggregation and the nuclear factorE2-related factor 2/heme oxygenase-1 pathway in iron-induced neurotoxicity. IntJ Biochem Cell Biol. 2013 Jun;45(6):1019-30
14. Bai L, Song N, Yu J, Tan L, Shen Y, Xie J*, Jiang H*. Elevated Plasma Levels of Soluble TNFRs and TACE Activity in Alzheimer's Disease Patients of Northern Han Chinese Descent. Current Alzheimer Research, 2013 Jan;10(1):57-62
15. Li C, Zhang F, Shi L, Zhang H, Tian Z, Xie J, Jiang H Nesfatin-1 Decreases Excitability of Dopaminergic Neurons in the Substantia Nigra. J Mol Neurosci. 2014 Mar;52(3):419-24.
16. Sun C, Song N, Xie A, Xie J, Jiang H*. High hepcidin level accounts for the nigral iron accumulation in acute peripheral iron intoxication rats. Toxicol Lett. 2012 Aug 3;212(3):276-81.
17. Jiang H, Hampel H, Prvulovic D, Wallin A, Blennow K, Li R, Shen Y. Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease. Mol Neurodegener. 2011 Oct 6;6:69.
18. He Q, Song N, Xu H, Wang R, Xie J, Jiang H*. Alpha-synuclein aggregation is involved in the toxicity induced by ferric iron to SK-N-SH neuroblastoma cells. J Neural Transm. 2011 Mar;118(3):397-406
19. He Q, Du T, Yu X, Xie A, Song N, Kang Q, Yu J, Tan L, Xie J, Jiang H*. DMT1 polymorphism and risk of Parkinson's disease. Neurosci Lett. 2011 Sep 1;501(3):128-31. Epub 2011 Jul 12.
获奖情况：
1. 《二价阳离子转运体1在帕金森病黑质铁聚积中的作用》于2013年获山东省科技进步二等奖，首位。
2. 《DMT1在帕金森病发病机制中的作用研究》于2009年获山东省科技进步三等奖，首位。
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