李琦，青岛大学基础医学院医学药理学系，讲师

个人简介

2021年8月 青岛大学 讲师

2016年9月-2021年7月 中国药科大学 硕博连读

2012年9月-2016年6月 中国药科大学 本科

主要研究方向

神经退行性疾病，小分子药物开发

代表性科研成果（^*为通讯作者）

1. Xiong B, Wang Y, Chen Y, Xing S, Liao Q, Chen Y, Li Q^*, Li W^*, Sun H^*. Strategies for Structural Modification of Small Molecules to Improve Blood-Brain Barrier Penetration: A Recent Perspective [J]. J Med Chem, 10.1021/acs.jmedchem.1c00910.

2. Li Q, Chen Y, Xing S, Liao Q, Xiong B, Wang Y, Lu W, He S, Feng F, Liu W^*, Chen Y^*, Sun H^*. Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection [J]. J Med Chem, 2021, 10.1021/acs.jmedchem.1c00167.

3. Li Q, Xing S, Chen Y, Liao Q, Xiong B, He S, Lu W, Liu Y, Yang H, Li Q, Feng F, Liu W, Chen Y^*, Sun H^*. Discovery and Biological Evaluation of a Novel Highly Potent Selective Butyrylcholinsterase Inhibitor [J]. J Med Chem, 2020, 63(17): 10030-10044.

4. Li Q, Xing S, Chen Y, Liao Q, Li Q, Liu Y, He S, Feng F, Chen Y, Zhang J, Liu W, Guo Q, Sun Y, Sun H*. Reasonably activating Nrf2: A long-term, effective and controllable strategy for neurodegenerative diseases [J]. Eur J Med Chem, 2020, 185: 111862.

5. Li Q, He S, Chen Y, Feng F, Qu W, Sun H^*. Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease [J]. Eur J Med Chem, 2018, 158: 463-477.

6. Li Q, Yang H, Chen Y, Sun H^*. Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease [J]. Eur J Med Chem, 2017, 132: 294-309.

7. Li Q, Yang H, Mo J, Chen Y, Wu Y, Kang C, Sun Y, Sun H^*. Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors [J]. PeerJ, 2018, 6: e4206.

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