一、个人简介

王瑾，青岛大学基础医学院病理系，

博士，讲师 。

二、主要研究方向

肿瘤耐药及靶向基因治疗机制

三、代表性科研成果

(1) Keyu Ren; Chunming Yong;Hao Yuan; Bin Cao; Kun Zhao; Jin Wang*, TNF-a inhibits SCF, ghrelin, and substance expressions through the NF-kB pathway activation in interstitial cells of Cajal. Journal of Medical and Biological Research, 2018, 51(6): e7065.

(2) Jin Wang ; Zhantao Liu; Dandan Zhang; Ranran Liu; Qian Lin; Jia Liu*; ZhihongYang; Qingxia Ma; Dantong Sun; Xin Zhou; Guohui Jiang* , FL118, anovel survivin inhibitor, wins the battle against drug-resistant and meta static lung cancers through inhibition of cancer stem cell-like properties, Am J Transl Res, 2017.8.30, 9(8): 3676-3686.

(3) Jin Wang ; Yunqing Chen; Fenggang Xiang; Min Li; Hong Li; Keyu Ren* , Suppression of TGF-β1 enhances chemosensitivity of cisplatin-resistant lung cancer cells through the inhibition of drug-resistant proteins, Artificial Cells, Nanomedicine, and Biotechnology, 2018, 46(7):1505-1512.

(4) Dandan Zhang ; Jin Wang(^#);Zhihong Yang; Jia Liu; Zhantao Liu; Lixia Ji; Ranran Liu; Qian Lin; Guohui Jiang*, A novel camptothecin analogue FL118 reduces cisplatin resistance of non-small cell lung cancer cells, Int J Clin Exp Med, 2016.6.30, 9(7): 13501-13513.

(5) Jin Wang ; Ke-Yu Ren; Pei-Xun Zhang; Yan-Hua Wang; Yu-Hui Kou;Jian-Ping Peng; Lei Deng; Hong-Bo Zhang; Bao-Guo Jiang* ,Effect of active Notch signaling system on the early repair of rat sciatic nerve injury, Artificial Cells, Nanomedicine and Biotechnology, 2014.5, 5(28): 1-7.

四、主持的科研项目

1.中国博士后科学基金面上资助项目，喜树碱类似物FL118在p68介导下对肺癌的抑制作用研究。

2.山东省医药卫生科技发展计划，沉默TGFβ1抑制肺腺癌干细胞作用机制的探讨。

3.山东省高等学校科技计划， siRNA沉默TGFβ1基因表达对肺癌顺铂耐药细胞的影响.

五、主要荣誉称号

2015年青岛大学“优秀班主任”

联系方式：

E-mail：jinsmile@126.com