刘雯

作者: 时间:2019-04-24 点击数:

刘雯,青岛大学基础医学院病原生物学系,博士,讲师

一、 个人简介

2004年至2008年就读于山东农业大学;2011年获得吉林大学硕士学位,硕士期间主要从事犬瘟热病毒组织病理损伤的研究;2011年10月获得国家留学基金委(CSC)资助赴德国攻读博士学位,先后在汉诺威兽医大学分子生物学实验室和罗斯托克大学医学院白血病与骨髓移植实验室进行B细胞淋巴瘤干细胞标记物筛选和小分子化合物吲哚马来酰亚胺诱导淋巴瘤细胞凋亡机制的研究,2015年12月获得博士学位。2016年入职青岛大学基础医学院病原生物学系,从事EB病毒相关肿瘤发生机制的研究。

二、 主要研究方向

EB病毒相关肿瘤

三、 代表性科研成果

1.Liu W, Xiao H, Wu S, Liu H, Luo B*. MAP9 single nucleotide polymorphism rs1058992 is a risk of EBV-associated gastric carcinoma in Chinese population. Acta Virol. 2018;62(4):435-440.

2.Liu W#, Beck J#, Schmidt LC, Roolf C, Pews-Davtyan A, Rutgen BC, Hammer S, Willenbrock S, Sekora A, Rolfs A, Beller M, Brenig B, Nolte I, Junghanss C, Schutz E, Murua Escobar H*. Characterization of the novel indolylmaleimides' PDA-66 and PDA-377 effect on canine lymphoma cells. Oncotarget. 2016; 7(23):35379-35389.

3.Liu W, Selcuk F, Rutgen BC, Moulay M, Willenbrock S, Hammer SE, Sterenczak KA, Junghanss C, Hewicker-Trautwein M, Nolte I, Murua Escobar H*. Evaluation of Stem Cell Marker Expression in Canine B-Cell Lymphoma Cell Lines, B-Cell Lymphoma-generated Spheres and Primary Samples. Anticancer Res. 2015; 35(5):2805-2816.

4.Liu W#, Moulay M#, Willenbrock S, Roolf C, Junghanss C, Ngenazahayo A, Nolte I, Murua Escobar H*. Comparative characterization of stem cell marker expression, metabolic activity and resistance to doxorubicin in adherent and spheroid cells derived from the canine prostate adenocarcinoma cell line CT1258. Anticancer Res. 2015; 35(4):1917-1927.

5. Taher L, Beck J,Liu W, Roolf C, Soller JT, Rütgen BC, Hammer SE, Chodisetti M, Sender S, Sterenczak KA, Fuellen G, Junghanss C, Brenig B, Nolte I, Schütz E, Murua Escobar H*. Comparative High-Resolution Transcriptome Sequencing of Lymphoma Cell Lines and de novo Lymphomas Reveals Cell-Line-Specific Pathway Dysregulation. Sci Rep. 2018; 8(1):6279.

6. Wang J,Liu W, Zhao Z, Zhang Y, Luo B*. Association of the Aquaporin 3 Gene Polymorphism (rs2231231) with Epstein-Barr Virus-Associated Cancers in China. Intervirology. 2018; 61(2):72-78.

7. Zhang Y, Zhang W,Liu W, Liu H, Zhang Y, Luo B*. Epstein-Barr virus miRNA-BART16 modulates cell proliferation by targeting LMP1. Virus Res. 2018; 256: 38-44.

8. Wu S,Liu W, Li H, Zhao Z, Yang Y, Xiao H, Song Y, Luo B*. Conservation and polymorphism of EBV RPMS1 gene in EBV-associated tumors and healthy individuals from endemic and non-endemic nasopharyngeal carcinoma areas in China. Virus Res. 2018; 250: 75-80.

9. Zhang Q,Liu W, Yang Y, Zhao Z, Luo B*. TM2D3 rs675436 or FGFR2 rs755793 polymorphisms and susceptibility to Epstein-Barr virus-associated tumors in Chinese Han population. J Med Virol. 2018; 90(6):1128-1133.

10. Xiao H,Liu W, Zhao Z, Zhang Y, Song Y, Luo B*. Single nucleotide polymorphism rs2274084 of gap junction protein beta 2 gene among Epstein-Barr virus-associated tumors. Cancer Biomark. 2018; 21(3):499-504.

11. Zhao Z,Liu W, Liu J, Wang J, Luo B*. The effect of EBV on WIF1, NLK, and APC gene methylation and expression in gastric carcinoma and nasopharyngeal cancer. J Med Virol. 2017; 89(10):1844-1851.

12. Yang Y,Liu W, Zhao Z, Zhang Y, Xiao H, Luo B*. Filaggrin gene polymorphism associated with Epstein-Barr virus-associated tumors in China.Virus Genes. 2017; 53(4):532-537.

13. Li J,Liu W, Che K, Zhang Y, Zhao Z, Luo B*.The Methylation Status and Expression of Epstein-Barr Virus Early Genes BARF1 and BHRF1 in Epstein-Barr Virus-Associated Gastric Carcinomas. Gastroenterol Res Pract. 2017; 2017:3804146.

14. Moulay M,Liu W, Willenbrock S, Sterenczak KA, Carlson R, Ngezahayo A, Murua Escobar H, Nolte I*. Evaluation of stem cell marker gene expression in canine prostate carcinoma- and prostate cyst-derived cell lines. Anticancer Res. 2013; 33(12):5421-5431.

四、 主持的科研项目

1.山东省自然科学基金(博士基金),ZR2017BH106,2017/08-2019/12,主持

2.青岛大学医学部“临床医学+x”工程项目,2017/09-2019/09,主持

3.中国博士后科学基金面上项目,2017/05-2018/12,主持

联系方式:E-mail:qdluobing@163.com

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