李琦，青岛大学基础医学院医学药理学系，副教授，山东省青年创新团队带头人，入选山东省青年科技人才托举工程
个人简介
2021年8月 青岛大学 副教授
2016年9月-2021年7月 中国药科大学 博士（硕博连读）
2012年9月-2016年6月 中国药科大学 本科
主要研究方向
神经退行性疾病与抗肿瘤小分子创新药物开发
代表性科研成果（*为通讯作者）
科研项目
1. 国家自然科学基金 82204202 主持
2. 山东省自然科学基金 ZR202111010031 主持
3. 山东省青年人才托举工程 SDAST2025 QTA052 主持
4. 山东省青年创新团队 2024KJJ049 团队带头人
5. 中国博士后科学基 2022M721758 主持
6. 青岛市博士后基金 QDBSH20220202182 主持
论文（*为通讯作者）
1. Z.Y. Lu, Q.H. Liao, Y.T. Duan, K.X. Wang, S.Y. He, W.P. Lyu, X.H. Chen, Q. Li*, Synergistic action of JNK activation and BChE inhibition: a novel anti- glioblastoma compound with neuroprotective profile, Future Med Chem, (2026).
2. S. Qi, L. Guo, J. Liang, K. Wang, Q. Liao, S. He, W. Lyu, Z. Cheng, J. Wang, X. Luo, X. Yan, Z. Lu, X. Wang, Z. Wang, X. Chen*, Q. Li*, A new strategy for the treatment of Parkinson's disease: Discovery and bio-evaluation of the first central-targeting tyrosinase inhibitor, Bioorg Chem, (2024)
3. Q. Li*, Q. Liao, S. Qi, H. Huang, S. He, W. Lyu, J. Liang, H. Qin, Z. Cheng, F. Yu, X. Dong, Z. Wang, L. Han, Y. Han, Opportunities and perspectives of small molecular phosphodiesterase inhibitors in neurodegenerative diseases, European journal of medicinal chemistry, (2024)
4. Z. Cheng, T. Han, J. Yao, K. Wang, X. Dong, F. Yu, H. Huang, M. Han, Q. Liao, S. He, W. Lyu, Q. Li*, Targeting glycogen synthase kinase-3beta for Alzheimer's disease: Recent advances and future Prospects, European journal of medicinal chemistry, (2024)
5. Q. Li*, S. Qi, J. Liang, Y. Tian, S. He, Q. Liao, S. Xing, L. Han, X. Chen, Review of triazole scaffolds for treatment and diagnosis of Alzheimer's disease, Chemico-biological interactions, 382 (2023)
6. W. Qiu, H. Liu, Y. Liu, X. Lu, L. Wang, Y. Hu, F. Feng, Q. Li*, H. Sun, Regulation of beta-amyloid for the treatment of Alzheimer's disease: Research progress of therapeutic strategies and bioactive compounds, Medicinal research reviews, (2023)
7. Y.Y. Wang, B.C. Xiong, S.S. Xing, Y. Chen, Q.H. Liao, J. Mo, Y. Chen, Q. Li*, H.P. Sun, Medicinal Prospects of Targeting Tyrosinase: A Feature Review, Curr Med Chem, (2023)
8. Q. Li, B. Xiong, Y. Wang, W. Lyu, S. Xing, Y. Chen, Q. Liao, S. He, F. Feng, W. Liu, Y. Chen, H. Sun, A highly effective and stable butyrylcholinesterase inhibitor with multi-faceted neuroprotection and cognition improvement, European journal of medicinal chemistry, (2022)
9. Q. Li, J. Mo, B.C. Xiong, Q.H. Liao, Y. Chen, Y.Y. Wang, S.S. Xing, S.Y. He, W.P. Lyu, N. Zhang, H.P. Sun, Discovery of Resorcinol-Based Polycyclic Structures as Tyrosinase Inhibitors for Treatment of Parkinson's Disease, Acs Chem Neurosci, (2022)
10. B. Xiong, Y. Wang, Y. Chen, S. Xing, Q. Liao, Y. Chen, Q. Li*, W. Li, H. Sun, Strategies for Structural Modification of Small Molecules to Improve Blood-Brain Barrier Penetration: A Recent Perspective, Journal of medicinal chemistry, (2021)
11. Q. Li, Y. Chen, S. Xing, Q. Liao, B. Xiong, Y. Wang, W. Lu, S. He, F. Feng, W. Liu, Y. Chen, H. Sun, Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection, Journal of medicinal chemistry, (2021)
学术任职
中国药理学会教学与科普专业委员会青年委员
山东药理学会药物毒理专业委员会委员
山东药理学会麻醉药理专业委员会委员
联系方式 Email：prettylucy@163.com
