个人简介模板:
薛美兰,青岛大学基础医学院生物化学与分子生物学系,博士,副教授,硕士生导师。
一、个人简介
近年来主持承担1项国家自然科学基金、1项省级自然科学基金面上项目和2项青岛市科研项目,参与多项国家级和省级科研项目。在国内外核心期刊发表医学论文40余篇,其中SCI收录论文20余篇,以第一作者在《J Nutr Biochem》、《Food Function》、《Nutr Cancer》等期刊发表SCI收录论文10篇,连续三年获得青岛大学青年卓越人才称号。
二、主要研究方向
天然海洋活性物质的功效评价、肿瘤预防与治疗。
三、代表性科研成果
1. Xue M, Ji X, Liang H*, Liu Y,Wang B, Sun L, Li W, The effect of fucoidan on intestinal flora and intestinal barrier function in rats with breast cancer, Food Funct, 2018, 9(2): 1214-1223
2. Xue M, Liang H*, Tang Q, Xue C, He X, Zhang L, Zhang Z, Liang Z, Bian K, Zhang L, Li Z, The Protective and Immunomodulatory Effects of Fucoidan Against 7,12-Dimethyl benz[a]anthracene-Induced Experimental Mammary Carcinogenesis Through the PD1/PDL1 Signaling Pathway in Rats, Nutr Cancer, 2017, 69(8): 1234-1244
3. Xue M, Ji X, Xue C, Liang H*, Ge Y, He X, Zhang L, Bian K, Zhang L, Caspase-dependent and caspase-independent induction of apoptosis in breast cancer by fucoidan via the PI3K/AKT/GSK3β pathway in vivo and in vitro, Biomed Pharmacother, 2017, 94: 898-908
4. Xue M#, Liu Y#, Lyu R, Ge N, Liu M, Ma Y, Liang H*, Protective effect of aplysin on liver tissue and the gut microbiota in alcohol-fed rats, PLoS One, 2017, 12(6): e0178684
5. Xue M, Wang Q, Zhao J, Dong L, Ge Y, Hou L, Liu Y, Zheng Z,Docosahexaenoic acid inhibited the Wnt/β-catenin pathway and suppressed breast cancer cells in vitro and in vivo, J Nutr Biochem, 2014, 25(2):104-110
6. 张 婷#,薛美兰#,刘 佳,刘 颖,梁争艳,梁 惠*,褐藻糖胶对乳腺肿瘤大鼠肠道屏障损伤的保护作用,营养学报,2018,40(1) :59 ~ 63
7. Xue M, Ge Y*, Yu C, Zheng Z, He X, Zhao J,Apoptosis is induced by docosahexaenoic acid in breast cancer cells via death receptor and mitochondria-mediated pathways, Mol Med Rep, 2017,16(1):978-982
8. Zhang X, Zhuang T, Liang Z, Li L, Xue M, Liu J, Liang H*, Breast cancer suppression by aplysin is associated with inhibition of PI3K/AKT/FOXO3a pathway,Oncotarget, 2017, 8(38): 63923-63934
9. Xue M,Ge Y,Zhang J,Liu Y,Wang Q,Hou L,Zheng Z, Fucoidan inhibited 4T1 mouse breast cancer cell growth in vivo and in vitro via downregulation of Wnt/β-catenin signaling,Nutr Cancer, 2013, 65(3): 460-468
10. Xue M,Ge Y*,Zhang J,Wang Q,Hou L,Liu Y,Sun L,Li Q, Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo,PLoS One, 2012, 7(8): e43483
11. Xue M,Ge Y,Zhang J,Wang Q,Hou L, Gene transfer of Chlorella vulgaris n-3 fatty acid desaturase optimizes the fatty acid composition of human breast cancer cells,Braz J Med Biol Res, 2012, 45(12): 1141-1149
四、主持的科研项目
1.青岛市民生科技计划项目,18-6-1-70-nsh,褐藻糖胶通过影响肠道微生态预防乳腺癌发生的作用机制,2018/09-2020/09,10万元,在研、主持
2.国家自然科学基金委青年基金,81502298,Periostin-avβ3-FAK-PI3K通路在褐藻糖胶抗乳腺癌转移中的作用机制研究,2016/01-2018/12,20.3万元,已结题,主持
3.青岛市博士后应用研究项目,2015165,基于TLR3/NF-κB信号通路探讨褐藻糖胶抗乳腺癌转移的作用及机制,2015/12-2017/07,5万,已结题,主持
4.山东省自然科学基金面上项目,ZR2014JL056,褐藻糖胶诱导人乳腺癌细胞发生线粒体途径凋亡的分子机制研究,2014/12-2017/12,18万元,已结题,主持
五、科研奖励
薛美兰(2/8),海藻生物活性物质抑制肿瘤增殖和对酒精性肝损伤的保护作用研究,中国医疗保健国际交流促进会,华夏医学科技奖,三等奖,2018
六、主要荣誉称号
1. 2017年,青岛大学教学十佳;
2. 2018年,青岛大学基础医学院优秀共产党员;
3. 2018年,青岛大学十佳优秀共产党员。
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