主要学术成果 科研项目: 目前在研项目 1.国家重点研发计划:iPSC-RPE治疗AMD和Stargardt病的多中心临床试验2017YFA0105303 2.山东省重点研发项目:AXL-CAR-T细胞联合溶瘤腺病毒rAd-GM-Decorin治疗乳腺癌骨转移临床前研究2019GSF108144 3.山东省自然科学基金:miRNA-17-92/A20/ACSL4信号轴在放射造血损伤及干祖细胞铁死亡中的作用与调控机制ZR2020MH327 著作教材: 1. 《再生医学学科发展战略》 科学出版社2015-(秘书组组长) 2. 付小兵,王正国,吴祖泽,主编《再生医学转化与应用》2017,人民卫生出版社 参编内容:《肝细胞生长因子基因治疗》 3. 《再生医学研究与转化应用》科学出版社2017-(秘书组组长) 期刊论文: 发表SCI论文90余篇,近期研究论文 1. Bai YT, Xiao FJ, Wang H, Ge RL, Wang LS.Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylation. Int J Med Sci. 2021;18(7):1618-1627. 2. Gao CC, Xu QQ, Xiao FJ, Wang H, Wu CT, Wang LS. NUDT21 suppresses the growth of small cell lung cancer by modulating GLS1 splicing. Biochem Biophys Res Commun. 2020;526(2):431-438. 3. Yuxiang Li, Fengjun Xiao, Aimei Zhang , Dan Zhang , Wenbo Nie , Tianxin Xu, Bing Han, Prem Seth, Hua Wang, Yuefeng Yang, Lisheng Wang . Oncolytic adenovirus targeting TGF-β enhances anti-Tumor responses of mesothelin-targeted chimeric antigen receptor T cell therapy against breast cancer. Cell Immunol 2020 2020;348:104041. 4. Wang LS, Wang H, Zhang QL, Yang ZJ, Kong FX, Wu CT.Hepatocyte Growth Factor Gene Therapy for Ischemic Diseases. Hum Gene Ther. 2018 ;29(4):413-423. 5. Liu Z, Yang Y, Zhang X, Wang H, Xu W, Wang H, Xiao F, Bai Z, Yao H, Ma X, Jin L, Wu CT, Seth P, Zhang Z, Wang L.An oncolytic adenovirus encoding decorin and GM-CSF inhibits tumor growth in a colorectal tumor model by targeting pro-tumorigenic signals and via immune-activation. Hum Gene Ther. 2017;28(8):667-680 |