主 要 学 术 成 果:
科研项目:
1. SUR1介导的KATP通道膜转运及其激活在帕金森病黑质多巴胺能神经元选择性损伤中的作用及机制探讨/国家自然科学基金,2016.1-2016.12 主持 2. AMPK-PKA-SUR1介导的 KATP通道激活参与黑质DA能神经元选择性损伤的机制研究/山东省教育厅,2016.01-2018.12,主持
3. SUR1/Kir6.2 型 KATP 通道在帕金森病发病中的/山东省博士后创新项目,2016.07-2017.12,主持
期刊论文:
1. Shi L1, Du X1, Jiang H*, Xie J*. Ghrelin and Neurodegenerative Disorders-a Review. Mol Neurobiol. 2016 Jan 26. (1Co-first authors,SCI收录,影响因子: 5.137)
2. Zhang Z, Du X, Xu H, Xie J, Jiang H. Lesion of medulla’s catecholaminergic neurons is associated with cardiovascular dysfunction in rotenone-induced Parkinson’s disease rats. Eur J Neurosci. 2015 Sep;42(6):2346-55. (SCI收录,影响因子:3.181)
3. Du X, Xu H, Jiang H, Xie J. Akt/Nrf2 activated upregulation of heme oxygenase-1 involves in the role of Rg1 against ferrous iron-induced neurotoxicity in SK-N-SH cells. Neurotox Res. 2013 Jul;24(1):71-9.(SCI收录,影响因子3.151)
4. Du X, Xu H, Jiang H, Song N, Wang J, Xie J*. Curcumin protects nigral dopaminergic neurons by iron-chelation in the 6-hydroxydopamine rat model of Parkinson's disease. Neurosci Bull. 2012 Jun; 28(3):253-8. (SCI收录,影响因子1.311)
5. Wang J1, Du X1, Jiang H, Xie J*. Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factor-kappaB modulation in MES23.5 cells. Biochem Pharmacol, 2009, Jul 15;78(2):178-83. Epub 2009 Apr 8.(1Co-first authors,SCI收录,影响因子4.254)
6. Wang J, Xu H, Yang H, Du X, Jiang H, Xie J*. Rg1 reduces nigral iron levels of MPTP-treated C57BL6 mice by regulating certain iron transport proteins. Neurochem Int. 2009 Jan;54(1):43-8.(SCI收录,影响因子3.541)
7. Wang J, Xu H, Jiang H, Du X, Sun P, Xie J. Neurorescue effect of rosmarinic acid on 6-hydroxydopamine-lesioned nigral dopamine neurons in rat model of Parkinson's disease. J Mol Neurosci. 2012 May;47(1):113-9. Epub 2011 Dec 29. (SCI收录,影响因子2.504)
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