主 要 学 术 成 果: (# 共同第一作者, *:通讯作者): Chen Z, Liu X, Li F, Li C, Marquez-Lago T, Leier A, Akutsu T, Webb GI, Xu D, Smith AI,Li L*, Chou KC*, Song J*. Large-scale comparative assessment of computational predictors for lysine post-translational modification sites. Briefings in Bioinformatics. 2018 Oct 4.(一区,IF:5.3;蛋白质修饰深度学习建模) Huang Y#, He N#, Chen Y, Chen Z*,Li L*. BERMP: a cross-species classifier for predicting m6A sites by integrating a deep learning algorithm and a random forest approach. Int J Biol Sci. 2018 14(12):1669-1677.(二区,IF:4.3,RNA修饰深度学习建模) Chen Z,He N,Huang Y,Qin WT,Liu X*,Li L*. Integration of A Deep Learning Classifier with A Random Forest Approach for Predicting Malonylation Sites.Genomics Proteomics Bioinformatics. 2018 16(6):451-459.(一区,IF:6.6,蛋白质修饰深度学习建模) Bian Y#,Li L#, Dong M#, Liu X, Kaneko T, Cheng K, Liu H, Voss C, Cao X, Wang Y, Litchfield D, Ye M*, Li SS*, Zou H*, Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder. Nat Chem Biol. 2016 12(11): 959-966.(Nature 子刊,IF: 13,蛋白质磷酸化修饰富集新方法及其在肿瘤靶向诊断中的应用) Li L, Wei Y, To C, Zhu CQ, Tong J, Pham NA, Taylor P, Ignatchenko V, Ignatchenko A, Zhang W, Wang D, Yanagawa N, Li M, Pintilie M, Liu G, Muthuswamy L, Shepherd FA, Tsao MS, Kislinger T, Moran MF*. Integrated omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact. Nat Communications. 2014 5:5469. (Nature 子刊,IF:11,肺癌大数据整合研究) Zaman N#,Li L#, Jaramillo ML, Sun Z, Tibiche C, Banville M, Collins C, Trifiro M, Paliouras M, Nantel A, O'Connor-McCourt M, Wang E*. Signaling network assessment of mutations and copy number variations predict breast cancer subtype-specific drug targets. Cell Reports. 2013, 5(1):216-23.(Cell 子刊,IF: 7,乳腺癌大数据整合研究以及应用于靶向药物筛选) Li L#, Tibiche C#, Fu C, Kaneko T, Moran MF, Schiller MR, Li SS*, Wang E*. The human phosphotyrosine signaling network: evolution and hotspots of hijacking in cancer. Genome Research. 2012, 22(7):1222-30.(一区,IF:14,蛋白质磷酸化修饰信号网络研究及其在肿瘤网络中的特征) 荣誉: 2014年山东省泰山学者海外特聘专家 2009年国际人体蛋白质组会议年轻研究员奖 基金情况: 山东省基金面上项目(2016.11-2019.6,18万元) 国家基金面上项目(2018.1-2012.12,60万元) 科研启动经费(200万) 泰山学者经费 |